Aminoadipate Aminotransferase (AADAT) Antibody
Pida mas información
935106861
info@markelab.com
Precio
416€ (200 µl)
Antibody anti-AADAT
proveedor
Abbexareference
abx432252Tested Applications
P-ELISA, IHCreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
AADAT Antibody is a Goat Polyclonal antibody against AADAT.
Background
Aminoadipate aminotransferase (AADAT), also known as kynurenine aminotransferase II (KAT II), is a mitochondrial enzyme that catalyzes the transamination of kynurenine to kynurenic acid (KYNA), a neuroactive metabolite in the kynurenine pathway of tryptophan metabolism. KYNA acts as an antagonist of NMDA and alpha-7 nicotinic acetylcholine receptors, regulating excitotoxicity and neuroinflammation in the brain. AADAT is expressed in various tissues, with high activity in the brain, where it influences neurotransmission and neuroprotection. Dysregulation of AADAT or kynurenine pathway metabolites has been linked to neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and schizophrenia, as well as cancer and immune-related disorders.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Aminoadipate Aminotransferase (AADAT)
host
Goat
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
P-ELISA, IHC
purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
recommended dilution
P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user.
buffer
Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin.
size 1
200 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
AADAT
dry ice
No
availability
Shipped within 5-10 working days.
alias
KAT2,KATII,KYAT2,Kynurenine Aminotransferase II
NCBI accession
NP_057312.1, NP_872603.1
note
Concentration: 0.5 mg/ml -
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