Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 1 (AIMP1) Antibody
416€ (200 µl)
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935106861
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name
Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 1 (AIMP1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx430476
tested applications
P-ELISA, WB, IHC
Description
AIMP1 Antibody is a Goat Polyclonal antibody against AIMP1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 1 (AIMP1) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB, IHC |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 9255 |
| NCBI Accession | NP_004748.2, NP_001135888.1 |
| Alias | p43,HLD3,EMAP2,SCYE1,EMAPII |
| Background | Antibody anti-AIMP1 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
AIMP1, also known as EMAP II (Endothelial Monocyte-Activating Polypeptide II), is a multifunctional protein that acts as a core component of the multi-aminoacyl-tRNA synthetase complex (MSC), which is essential for protein synthesis. It interacts with various aminoacyl-tRNA synthetases to maintain the stability and functionality of the complex. Beyond its role in translation, AIMP1 has extracellular signaling functions, particularly in modulating immune responses and angiogenesis. When secreted, AIMP1 functions as a cytokine that activates monocytes and endothelial cells, contributing to inflammatory responses and tissue repair. It is also involved in apoptosis, cellular stress responses, and tumor suppression. Dysregulation of AIMP1 is associated with cancer progression, inflammatory diseases, and autoimmune disorders, highlighting its dual roles in intracellular protein synthesis and extracellular signaling.
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