Alpha-Hemoglobin Stabilizing Protein (aHSP) Antibody (Biotin)
351€ (200 µl)
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935106861
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name
Alpha-Hemoglobin Stabilizing Protein (aHSP) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx271981
tested applications
WB, IHC, IF/ICC
Description
Alpha-Hemoglobin Stabilizing Protein (aHSP) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin against Alpha-Hemoglobin Stabilizing Protein (aHSP).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Alpha-Hemoglobin Stabilizing Protein (aHSP) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.5-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 200 µl |
| Size 2 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | EDRF,ERAF |
| Background | Antibody anti-AHSP |
| Status | RUO |
Descripción
Alpha Hemoglobin Stabilizing Protein (AHSP) is a molecular chaperone that specifically binds to free alpha-globin subunits during erythropoiesis, stabilizing them and preventing their aggregation or precipitation. This function is critical for maintaining the proper stoichiometry of alpha- and beta-globin chains required for the assembly of functional hemoglobin tetramers. AHSP also protects alpha-globin from oxidative damage by maintaining it in a reduced state. Dysregulation or deficiency of AHSP is associated with hematological disorders such as beta-thalassemia, where excess alpha-globin chains lead to oxidative stress and ineffective erythropoiesis. AHSP is highly expressed in erythroid precursor cells, and its expression is tightly regulated during red blood cell development. Therapeutic approaches that modulate AHSP levels or function are being explored as potential treatments for thalassemias and related hemoglobinopathies.
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