Alpha-Fetoprotein (AFP) Antibody
292.5€ (80 µl)
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name
Alpha-Fetoprotein (AFP) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx025195
tested applications
ELISA, WB
Description
alpha 1 Fetoprotein encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Alpha-Fetoprotein (AFP) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1/31.25. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgM |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P02771 |
| Alias | HPAFP,Alpha fetoglobulin |
| Background | Antibody anti-AFP |
| Status | RUO |
Descripción
Alpha-fetoprotein (AFP) is a protein that is normally produced by the liver and yolk sac of a developing fetus. It is also produced in small quantities by the fetal gastrointestinal tract. AFP levels are typically high in the fetus, but they decrease rapidly after birth and remain low in healthy adults. AFP is considered a marker of fetal development. During pregnancy, AFP levels can be measured in the mother's blood or amniotic fluid as part of prenatal screening tests. Abnormal levels of AFP may indicate certain developmental abnormalities, such as neural tube defects (e.g., spina bifida) or chromosomal abnormalities (e.g., Down syndrome).Elevated levels of AFP in the blood can also be indicative of certain types of cancer, particularly liver cancer (hepatocellular carcinoma) and certain germ cell tumors. In patients with liver cancer, AFP levels may be used as a tumor marker to monitor disease progression and response to treatment. However, it's important to note that not all cases of liver cancer produce elevated AFP levels, and AFP levels can also be elevated in other conditions, such as cirrhosis and hepatitis.AFP testing is commonly used in clinical practice for various purposes:Prenatal Screening, AFP Cancer Diagnosis and Monitoring, and Monitoring Liver Disease
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