Alpha- And Gamma-Adaptin-Binding Protein P34 (AAGAB) Antibody
169€ (20 µg)
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Name
Alpha- And Gamma-Adaptin-Binding Protein P34 (AAGAB) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx333825
Tested Applications
ELISA, IHC, IF/ICC
Description
AAGAB Antibody is a Rabbit Polyclonal against AAGAB.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Alpha- And Gamma-Adaptin-Binding Protein P34 (AAGAB) Immunogen: Recombinant Human Alpha- and gamma-adaptin-binding protein p34 protein (191-315AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6PD74 |
| Gene ID | 79719 |
| Alias | p34,PPP1,PPKP1,PPKP1A |
| Background | Antibody anti-AAGAB |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Alpha- and Gamma-Adaptin-Binding Protein P34 (AAGAB) is a cytoplasmic protein that interacts with adaptin proteins, which are part of the clathrin-mediated endocytosis machinery. AAGAB plays a crucial role in regulating vesicular trafficking, including the internalization and recycling of cell surface receptors and membrane proteins. It is involved in maintaining cellular homeostasis by mediating the transport of molecules between the plasma membrane, endosomes, and other intracellular compartments. Mutations in the AAGAB gene are linked to palmoplantar keratoderma (PPK), a skin disorder characterized by hyperkeratosis of the palms and soles, due to defective vesicular transport and keratinocyte function. Emerging research suggests that AAGAB may also influence cell signaling and proliferation through its role in membrane protein trafficking. Its importance in cellular dynamics highlights its potential as a target for understanding and treating vesicle transport-related disorders.
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