Alpha-actinin-3 (ACTN3) Antibody
169€ (20 µg)
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935106861
info@markelab.com
name
Alpha-actinin-3 (ACTN3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx341191
tested applications
ELISA, IF/ICC
Description
Alpha-actinin-3 (ACTN3) Antibody is a Rabbit Polyclonal antibody for the detection of Human ACTN3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Alpha-actinin-3 (ACTN3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G chromatography. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q08043 |
| Alias | ACTN3D |
| Background | Antibody anti-ACTN3 |
| Status | RUO |
Descripción
ACTN3 encodes alpha-actinin-3, a protein primarily expressed in fast-twitch skeletal muscle fibers, where it contributes to muscle strength and power. Unlike its closely related isoform ACTN2, ACTN3 is specialized for rapid and forceful contractions, playing a structural role in maintaining sarcomeric integrity and optimizing muscle performance. A common polymorphism in the ACTN3 gene results in the absence of alpha-actinin-3 in a significant proportion of the population, which has been associated with variations in muscle performance. The "null" variant is linked to reduced muscle power but enhanced endurance, reflecting its evolutionary role in adapting to physical demands. ACTN3 is crucial in regulating the balance between muscle power and endurance, with implications in athletic performance, muscle health, and susceptibility to muscle-related disorders.
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