Alpha-1-Acid Glycoprotein 1 (ORM1) Antibody
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935106861
info@markelab.com
Precio
195€ (20 µl)
Antibody anti-ORM1
proveedor
Abbexareference
abx001490Tested Applications
ELISA, WBreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalDescripción
Orosomucoid 1 Antibody is a Rabbit Polyclonal antibody against Orosomucoid 1. Alpha-1-acid glycoprotein 1 (AGP1), also called orosomucoid-1 (Orosomucoid 1), is a glycoprotein synthesized mostly by hepatocytes and present in human plasma. Orosomucoid 1 is an acute-phase reactant protein controlled by glucocorticoids, interleukin-1 and interleukin-6, and increase up to 5-50 times upon infection and/or inflammation. Anti-apoptotic effect and role as immunomodulator of ORM have been reported. ORM is an important carrier for synthetic drugs and influences their distribution and availability in the body. This antibody recognizes a band about 44 kDa in human plasma which may be due to the glycosylation of Orosomucoid 1 or the dimer formation of the protein.
Background
Alpha-1-Acid Glycoprotein (ORM1), also known as orosomucoid, is an acute-phase plasma protein predominantly synthesized in the liver. ORM1 is a part of the acute-phase response, where its levels in the blood increase in response to inflammation, infection, or injury.It is a 43-44 kDa glycoprotein well known as a one of the major acute phase proteins in humans, rats and many other spices The carbohydrate content represents 45% of the molecular weight attached in the form of five to six highly sialylated complex-type-N-linked glycans.ORM1 has since been studied extensively for its role in immune regulation, drug binding, and inflammation.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse, Rat
immunogen target
Alpha-1-Acid Glycoprotein 1 (ORM1)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB
purification
Purified by affinity chromatography.
recommended dilution
ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
size 1
20 µl
size 2
100 µl
size 3
2 × 100 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
ORM1
dry ice
No
availability
Shipped within 5-10 working days.
alias
Alpha-1-Acid Glycoprotein/orm1,Orosomucoid-1,OMD 1,Orosomucoid 1
uniprot id
NCBI accession
NP_000598.2
note
Concentration: > 0.2 mg/ml -
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