Allograft Inflammatory Factor 1 (AIF1) Antibody
195€ (20 µl)
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935106861
info@markelab.com
name
Allograft Inflammatory Factor 1 (AIF1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx002264
tested applications
ELISA, IHC, IF/ICC
Description
AIF1 Antibody is a Rabbit Polyclonal antibody against AIF1. This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. Three transcript variants encoding different isoforms have been found for this gene.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Allograft Inflammatory Factor 1 (AIF1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1 µg/ml, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P55008 |
| Gene ID | 199 |
| OMIM | 601833 |
| Alias | AIF-1,IBA1,IRT-1,IRT1 |
| Background | Antibody anti-AIF1 |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
AIF1 is an inflammation-responsive protein primarily expressed in macrophages, microglia, and other immune cells. It plays a critical role in immune regulation, particularly in modulating inflammatory responses, cell migration, and phagocytosis. Structurally, AIF1 contains EF-hand calcium-binding motifs, enabling it to respond to changes in intracellular calcium levels, which are key to immune cell activation and signaling. AIF1 is upregulated during inflammatory diseases such as autoimmune disorders, transplant rejection, and atherosclerosis, where it contributes to immune cell recruitment and tissue remodeling. It is also involved in promoting macrophage activation and migration to sites of injury or infection. Dysregulated AIF1 expression is associated with chronic inflammation, cancer progression, and neuroinflammatory diseases like multiple sclerosis, making it a potential biomarker and therapeutic target for inflammatory and immune-related disorders.
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