AlkB Homolog 5, RNA Demethylase (ALKBH5) Antibody

Este producto es parte de ALKBH - alkB homolog
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312€ (60 µl)

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935106861
info@markelab.com
name
AlkB Homolog 5, RNA Demethylase (ALKBH5) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx125516
tested applications
WB, IHC

Description

ALKBH5 Antibody is a Rabbit Polyclonal against ALKBH5.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
AlkB Homolog 5, RNA Demethylase (ALKBH5)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by affinity chromatography.
Size 1
60 µl
Size 2
120 µl
Size 3
200 µl
Form
Liquid
Tested Applications
WB, IHC
Buffer
PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q6P6C2
Gene ID
54890
NCBI Accession
NP_060228.3
Alias
ALKBH5,ABH5,OFOXD1
Background
Antibody anti-ALKBH5
Status
RUO
Note
Concentration: 1 mg/ml - 

Descripción

ALKBH5 is an α-ketoglutarate (α-KG)- and Fe(II)-dependent dioxygenase that specifically catalyzes the demethylation of N6-methyladenosine (m6A), a major modification on mRNA. ALKBH5 is a key regulator of RNA metabolism, influencing mRNA stability, splicing, translation, and export. By removing m6A marks, ALKBH5 modulates gene expression, particularly during processes such as spermatogenesis, immune responses, and cancer progression. ALKBH5 is highly expressed in testicular tissues, where it regulates germ cell development and fertility. In cancer biology, ALKBH5 plays a critical role in tumor progression and metastasis by promoting the stability and translation of oncogenes and cancer-associated transcripts. Its upregulation has been observed in glioblastoma, breast cancer, and other tumors, where it contributes to chemoresistance and proliferation. Recent studies highlight ALKBH5 as a potential therapeutic target for disrupting cancer-associated RNA modifications and inhibiting tumor growth.

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