AlkB Homolog 4, Lysine Demethylase (ALKBH4) Antibody

Este producto es parte de ALKBH - alkB homolog
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357.5€ (100 µg)

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935106861
info@markelab.com
name
AlkB Homolog 4, Lysine Demethylase (ALKBH4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx036144
tested applications
ELISA, WB, IHC

Description

Rabbit Polyclonal against the ALKBH4 protein.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
AlkB Homolog 4, Lysine Demethylase (ALKBH4)
Host
Rabbit
Reactivity
Human
Recommended Dilution
ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by antigen affinity column chromatography.
Size 1
100 µg
Size 2
1 mg
Form
Lyophilized
Tested Applications
ELISA, WB, IHC
Buffer
Prior to lyophilization: 1% BSA and 0.02% NaN3.
Availability
Shipped within 7-15 working days.
Storage
Store at -20 °C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
ALKBH4,ABH4
Background
Antibody anti-ALKBH4
Status
RUO
Note
Concentration: Lyophilized form: Not applicable.  After reconstitution: 1 mg/ml. -

Descripción

ALKBH4 is a nuclear enzyme that functions as a lysine demethylase, specifically targeting methylated lysine residues on non-histone proteins. ALKBH4 plays a critical role in cytoskeletal dynamics, particularly by demethylating actin, which regulates actin filament assembly and cellular motility. Its activity ensures proper cytokinesis, cell shape maintenance, and migration during mitosis and development. ALKBH4 also participates in DNA repair and gene regulation by interacting with other proteins involved in chromatin remodeling and transcription. Dysregulation of ALKBH4 is linked to defects in cell division, genomic instability, and impaired cellular motility, contributing to developmental abnormalities and cancer progression. In cancer biology, ALKBH4’s regulation of cytoskeletal dynamics has been shown to promote cancer cell invasion and metastasis. Its role in demethylating non-histone proteins distinguishes ALKBH4 from other ALKB family members, highlighting its importance in post-translational modification and cellular homeostasis.

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