AlkB Homolog 3, Alpha-Ketoglutaratedependent Dioxygenase (ALKBH3) Antibody

Este producto es parte de ALKBH - alkB homolog
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364€ (100 µg)

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935106861
info@markelab.com
name
AlkB Homolog 3, Alpha-Ketoglutaratedependent Dioxygenase (ALKBH3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx230312
tested applications
ELISA, WB, IHC

Description

ALKBH3 Antibody is a Rabbit Polyclonal against ALKBH3.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
AlkB Homolog 3, Alpha-Ketoglutaratedependent Dioxygenase (ALKBH3)
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
WB: 1/500 - 1/5000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purity
≥ 95% (SDS-PAGE)
Purification
Purified by immunogen affinity chromatography.
Size 1
100 µg
Form
Liquid
Tested Applications
ELISA, WB, IHC
Buffer
PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Availability
Shipped within 5-12 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q96Q83
Gene ID
221120
OMIM
610603
Alias
ALKBH3,ABH3,DEPC1
Background
Antibody anti-ALKBH3
Status
RUO
Note
Concentration: 2 mg/ml - Validity: 12 months.

Descripción

ALKBH3 is an α-KG- and Fe(II)-dependent dioxygenase that repairs methylated lesions on single-stranded DNA (ssDNA) and RNA. It specifically removes alkylation damage, such as N1-methyladenine (m1A) and N3-methylcytosine (m3C), restoring nucleic acid integrity and ensuring proper transcription and translation. ALKBH3 exhibits a preference for repairing damage in RNA, including tRNA, rRNA, and mRNA, where it preserves their structural stability and functionality. ALKBH3 interacts with ASCC3 helicase, which unwinds damaged regions of DNA/RNA, facilitating repair. Its role in RNA demethylation highlights its importance in regulating gene expression and protein synthesis. Overexpression of ALKBH3 has been observed in various cancers, including prostate, pancreatic, and lung cancers, where it contributes to tumor cell proliferation, survival, and resistance to alkylating agents. Targeting ALKBH3 has been explored as a therapeutic approach for sensitizing cancer cells to chemotherapy and inhibiting tumor growth.

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