AlkB Homolog 3, Alpha-Ketoglutaratedependent Dioxygenase (ALKBH3) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Rabbit Polyclonal against the ALKBH3 protein.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | AlkB Homolog 3, Alpha-Ketoglutaratedependent Dioxygenase (ALKBH3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ALKBH3,ABH3,DEPC1 |
| Background | Antibody anti-ALKBH3 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
ALKBH3 is an α-KG- and Fe(II)-dependent dioxygenase that repairs methylated lesions on single-stranded DNA (ssDNA) and RNA. It specifically removes alkylation damage, such as N1-methyladenine (m1A) and N3-methylcytosine (m3C), restoring nucleic acid integrity and ensuring proper transcription and translation. ALKBH3 exhibits a preference for repairing damage in RNA, including tRNA, rRNA, and mRNA, where it preserves their structural stability and functionality. ALKBH3 interacts with ASCC3 helicase, which unwinds damaged regions of DNA/RNA, facilitating repair. Its role in RNA demethylation highlights its importance in regulating gene expression and protein synthesis. Overexpression of ALKBH3 has been observed in various cancers, including prostate, pancreatic, and lung cancers, where it contributes to tumor cell proliferation, survival, and resistance to alkylating agents. Targeting ALKBH3 has been explored as a therapeutic approach for sensitizing cancer cells to chemotherapy and inhibiting tumor growth.
Related Products
anti- ALKBH3 antibody
ALKBH3, also named as ABH3 and DEPC-1, is a dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A). It has a strong preference for single-stranded. ALKBH3 is requires molecular oxygen, alpha-ketoglutarate and iron. This gene has some isoforms with MW 19-25 kDa and 33 kDa.
Ver Producto
Recombinant Human ALKBH3
Ver Producto
AlkB Homolog 3, Alpha-Ketoglutaratedependent Dioxygenase (ALKBH3) Antibody
ALKBH3 Antibody is a Rabbit Polyclonal antibody against ALKBH3. The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002.
Ver Producto