Alkaline Phosphatase, Tissue-Nonspecific Isozyme (ALPL) Antibody

Descripción

Alkaline Phosphatase, Tissue-Nonspecific Isozyme (ALPL) Antibody is a Rabbit Polyclonal antibody for the detection of ALPL. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. ALPL (Alkaline phosphatase, tissue-nonspecific isozyme) is also named as AP-TNAP, TNSALP and belongs to the alkaline phosphatase family. It can exsit as a homodimer with the molecular weight of 140 kDa (PMID:18724009). ALPL was synthesized as a 66-kDa endo-b-N-acetylglucos-aminidase H (Endo H) -sensitive form, and processed to an 80-kDa mature form, which is anchored to the plasma membrane via glycosylphosphatidylinositol (GPI) (PMID:10839996).This antibody can bind the four mentioned alkaline phosphatases.