Alkaline Phosphatase, Tissue-Nonspecific Isozyme (ALPL) Antibody

Este producto es parte de ALPL - Alkaline phosphatase tissue-nonspecific isozyme
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292.5€ (80 µl)

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935106861
info@markelab.com
name
Alkaline Phosphatase, Tissue-Nonspecific Isozyme (ALPL) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx028274
tested applications
ELISA, WB, IHC, IF/ICC, FCM

Description

Alkaline Phosphatase, Tissue-Nonspecific Isozyme (ALPL) Antibody is a rabbit polyclonal antibody for ALPL. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). This protein is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to a disorder known as hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms.

Documents del producto

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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
Alkaline Phosphatase, Tissue-Nonspecific Isozyme (ALPL)
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
WB: 1/2000, IHC-P: 1/500, IF/ICC: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified through a protein A column, followed by peptide affinity purification.
Size 1
80 µl
Size 2
400 µl
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF/ICC, FCM
Buffer
PBS containing 0.09% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P05186
NCBI Accession
NP_000469.3, NP_001120973.2, NP_001170991.1
Alias
AP-TNAP,TNS-ALP
Background
Antibody anti-ALPL
Status
RUO
Note
Concentration: 0.5 mg/ml -

Descripción

Alkaline phosphatase, tissue-nonspecific isozyme (ALPL) is an enzyme encoded by the ALPL gene in humans. It is also commonly known as tissue-nonspecific alkaline phosphatase (TNAP). ALPL is a type of alkaline phosphatase found in bone, liver, kidney, and intestine. ALPL plays a crucial role in bone mineralization and is involved in the regulation of phosphate metabolism. It catalyzes the hydrolysis of phosphate esters in an alkaline environment, leading to the release of inorganic phosphate. In bone tissue, ALPL is primarily expressed by osteoblasts, where it helps in the mineralization process by generating inorganic phosphate ions, which are essential for the formation of hydroxyapatite crystals, the main component of bone mineral. Deficiencies or mutations in the ALPL gene can lead to a rare genetic disorder known as hypophosphatasia (HPP). HPP is characterized by defective bone mineralization, resulting in weak and soft bones, skeletal abnormalities, and a range of other symptoms depending on the severity of the condition.

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