Intestinal-Type Alkaline Phosphatase / IAP (ALPI) Antibody

Este producto es parte de ALPI - Intestinal-type alkaline phosphatase
Intestinal-Type Alkaline Phosphatase / IAP (ALPI) Antibody

Pida mas información

935106861

info@markelab.com

Precio

273€ (100 µl)

Antibody anti-ALPI

proveedor

Abbexa

reference

abx101822

Tested Applications

WB, IHC, IF/ICC

reactivity

Human

status

RUO

clonality

Polyclonal

Descripción

Polyclonal Antibody to Alkaline Phosphatase (ALP).


Background

Intestinal-type alkaline phosphatase (ALPI) is a glycoprotein enzyme primarily expressed on the luminal surface of intestinal epithelial cells, particularly in the small intestine. It plays a crucial role in maintaining gut homeostasis by detoxifying lipopolysaccharides (LPS), dephosphorylating inflammatory mediators, and promoting a healthy microbiota. ALPI is also involved in nutrient absorption, such as the hydrolysis of dietary phosphate esters, contributing to the regulation of phosphate metabolism. Its expression is upregulated in response to inflammation and microbial imbalance, acting as a protective mechanism against intestinal permeability and systemic endotoxemia. Additionally, ALPI prevents excessive immune activation by neutralizing pro-inflammatory signals, which is essential for preventing conditions such as inflammatory bowel disease (IBD) and sepsis. Alterations in ALPI expression or activity have been linked to gastrointestinal disorders, including Crohn's disease and ulcerative colitis. Its multifunctional role highlights its importance in gut health, immune modulation, and overall metabolic regulation.

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Human


immunogen target

Intestinal-Type Alkaline Phosphatase / IAP (ALPI)


host

Rabbit


conjugation

Unconjugated


form

Liquid


tested applications

WB, IHC, IF/ICC


purification

Purified by antigen-specific affinity chromatography , followed by Protein A affinity chromatography.


recommended dilution

WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.


buffer

0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.


size 1

100 µl


size 2

200 µl


size 3

1 ml


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

ALPI


dry ice

No


availability

Shipped within 5-7 working days.


alias

IAP


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