ALK Tyrosine Kinase Receptor (ALK) Cell ELISA Kit
513.5€ (96 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
ALK Tyrosine Kinase Receptor (ALK) Cell ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx595026
Tested Applications
ELISA
Description
ALK Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Immunogen Target | ALK Tyrosine Kinase Receptor (ALK) |
| Reactivity | Human, Mouse |
| Detection Method | Colorimetric |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Tested Applications | ELISA |
| Availability | Shipped within 1-2 weeks. |
| Storage | Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9UM73 |
| Gene ID | 238 |
| OMIM | 105590 |
| Alias | CD246 |
| Background | Elisa Kits for: ALK |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Background
The ALK (anaplastic lymphoma kinase) gene encodes a receptor tyrosine kinase, which is a type of cell surface receptor that plays a role in signaling pathways involved in cell growth, proliferation, and differentiation. The ALK protein belongs to the insulin receptor superfamily and is normally expressed in specific tissues during embryonic development, where it helps regulate normal cell growth and development. While ALK expression is typically limited to certain tissues during development, aberrant activation of the ALK gene can occur in various cancers due to chromosomal rearrangements, gene amplification, or activating mutations. These alterations lead to the overexpression or constitutive activation of the ALK protein, contributing to oncogenesis (the formation of cancer).The most well-known oncogenic alteration involving the ALK gene is the fusion of the ALK gene with another gene, resulting in a chimeric fusion protein with constitutive kinase activity. This fusion protein can drive cellular transformation and tumorigenesis.
Productos relacionados
ALK Tyrosine Kinase Receptor Phospho-Tyr1604 (ALK pY1604) Antibody
Rabbit polyclonal antibody against ALK protein. Immunogen region is C-terminal. Specificity is as follows for the reacti…
Ver producto
ALK Tyrosine Kinase Receptor Phospho-Tyr1096 (ALK pY1096) Antibody
Rabbit polyclonal antibody against ALK protein. Immunogen region is Internal. Specificity is as follows for the reactive…
Ver producto
ALK Tyrosine Kinase Receptor (ALK) Antibody
Rabbit polyclonal antibody against ALK protein. Immunogen region is C-terminal.…
Ver producto