ALK Tyrosine Kinase Receptor (ALK) Antibody
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Description
ALK Tyrosine Kinase Receptor (ALK) Antibody is a Mouse Monoclonal antibody for the detection of ALK Tyrosine Kinase Receptor (ALK) in Human samples.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ALK Tyrosine Kinase Receptor (ALK) |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 Kappa |
| Clone ID | X754 |
| Purity | > 95% |
| Purification | Purified by Protein A/G affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | FCM |
| Buffer | 0.01 M PBS, pH 7.4. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 4 °C if the entire vial will be used within 1 week. Aliquot and store at -20 °C or -80 °C for long-term storage. Avoid repeated freeze-thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UM73 |
| Gene ID | 238 |
| NCBI Accession | NP_004295.2 |
| Alias | CD246 |
| Background | Antibody anti-ALK |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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ALK antibody
Anaplastic Lymphoma Kinase (ALK), also known as CD246, is a 220 kDa transmembrane glycoprotein that is primarily expressed in the developing nervous system. ALK contains one LDL Receptor (LDLR) class A domain, two meprin/A5-protein/PTPmu (MAM) domains, and a cytoplasmic kinase domain. Chromosomal translocation involving ALK and the nucleolar NPM protein result in a cytoplasmic fusion protein that exists as a dimer. The kinase domain in NPM-ALK is constitutively active and participates in cellular transformation. ALK translocations are found in a variety of tumors. Within the extracellular domain, human and mouse ALK share 88% amino acid sequence identity.
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