ALK Tyrosine Kinase Receptor (ALK) Antibody
383.5€ (100 µl)
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Name
ALK Tyrosine Kinase Receptor (ALK) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx224320
Tested Applications
ELISA, IHC, IF/ICC, FCM
Description
ALK Antibody is a Mouse Monoclonal against ALK.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: ALK Tyrosine Kinase Receptor (ALK) Immunogen: Purified recombinant fragment of human ALK (AA: 1366-1468) expressed in E. coli. |
| Host | Mouse |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | ELISA: 1/10000, IHC: 1/200 - 1/1000, IF/ICC: 1/50 - 1/250, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Observed MW | 26.4 kDa |
| Purification | Purified from ascites by Protein G chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC, IF/ICC, FCM |
| Buffer | PBS, containing 0.05% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q15848 |
| Gene ID | 9370 |
| OMIM | 125853 |
| Alias | CD246 |
| Background | Antibody anti-ALK |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
The ALK (anaplastic lymphoma kinase) gene encodes a receptor tyrosine kinase, which is a type of cell surface receptor that plays a role in signaling pathways involved in cell growth, proliferation, and differentiation. The ALK protein belongs to the insulin receptor superfamily and is normally expressed in specific tissues during embryonic development, where it helps regulate normal cell growth and development. While ALK expression is typically limited to certain tissues during development, aberrant activation of the ALK gene can occur in various cancers due to chromosomal rearrangements, gene amplification, or activating mutations. These alterations lead to the overexpression or constitutive activation of the ALK protein, contributing to oncogenesis (the formation of cancer).The most well-known oncogenic alteration involving the ALK gene is the fusion of the ALK gene with another gene, resulting in a chimeric fusion protein with constitutive kinase activity. This fusion protein can drive cellular transformation and tumorigenesis.
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