Aldo-Keto Reductase Family 1 Member C3 (AKR1C3) Antibody

Este producto es parte de AKR1C- Aldo-keto reductase family 1 member C
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442€ (200 µl)

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935106861
info@markelab.com
name
Aldo-Keto Reductase Family 1 Member C3 (AKR1C3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx432302
tested applications
P-ELISA, WB, IHC

Description

AKR1C3 Antibody is a Goat Polyclonal antibody against AKR1C3.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Target: Aldo-Keto Reductase Family 1 Member C3 (AKR1C3)
Immunogen: abx269622 - C-Terminus: CFASHPNYPYSDEY
Host
Goat
Reactivity
Human
Assay Type
Concentration: 0.5 mg/ml
Recommended Dilution
P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Size 1
200 µl
Form
Liquid
Tested Applications
P-ELISA, WB, IHC
Buffer
Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Gene ID
8644
NCBI Accession
NP_003730.4
Alias
AKR1C3, DDH1, HSD17B5, KIAA0119, PGFS
Background
Antibody anti-AKR1C3
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Descripción

AKR1C3, also known as 17β-hydroxysteroid dehydrogenase type 5, is a multifunctional enzyme involved in the metabolism of steroid hormones, prostaglandins, and xenobiotics. AKR1C3 converts androstenedione to testosterone and estrone to estradiol, playing a central role in androgen and estrogen biosynthesis. It also reduces prostaglandin D2 to PGF2α, influencing inflammation, immune responses, and cell proliferation. AKR1C3 is overexpressed in hormone-dependent cancers, such as prostate, breast, and endometrial cancers, where it promotes tumor growth by enhancing local androgen and estrogen production. Its ability to detoxify lipid peroxidation products like 4-HNE also confers resistance to oxidative stress and chemotherapy. AKR1C3 is emerging as a therapeutic target in cancer, particularly in castration-resistant prostate cancer, where it sustains androgen receptor signaling. In addition to cancer, AKR1C3 regulates neurosteroids and prostaglandin pathways, linking it to inflammation, neuroprotection, and metabolic diseases.
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