Aldehyde Dehydrogenase Family 1 Member A3 (ALDH1A3) Antibody (HRP)
169€ (20 µg)
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935106861
info@markelab.com
name
Aldehyde Dehydrogenase Family 1 Member A3 (ALDH1A3) Antibody (HRP)
category
Primary Antibodies
provider
Abbexa
reference
abx314746
tested applications
ELISA
Description
ALDH1A3 Antibody (HRP) is a Rabbit Polyclonal against ALDH1A3 conjugated to HRP.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Aldehyde Dehydrogenase Family 1 Member A3 (ALDH1A3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P47895 |
| Gene ID | 220 |
| OMIM | 600463 |
| Alias | ALDH1A3, ALDH6 |
| Background | Antibody anti-ALDH1A3 |
| Status | RUO |
Descripción
ALDH1A3 is a cytosolic enzyme that catalyzes the irreversible oxidation of retinaldehyde to retinoic acid, an essential signaling molecule that regulates gene expression during development, tissue homeostasis, and differentiation. ALDH1A3 plays a pivotal role in retinoic acid synthesis, particularly in the nervous system, epithelial tissues, and metabolic organs. Its expression is highly regulated during embryogenesis, where it influences organ patterning, neurogenesis, and craniofacial development. ALDH1A3 is often overexpressed in various cancers, including glioblastoma, breast cancer, and lung cancer, where it functions as a marker for cancer stem cells (CSCs), promoting tumor initiation, chemoresistance, and metastasis. Beyond its role in cancer, ALDH1A3 is involved in lipid and glucose metabolism, and its dysregulation has been linked to metabolic disorders such as obesity and diabetes. Recent studies highlight ALDH1A3 as a potential therapeutic target for blocking CSC-mediated tumor progression and metabolic dysfunction.
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