Aldehyde Dehydrogenase 6 Family Member A1 (ALDH6A1) Antibody (FITC)
169€ (20 µg)
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name
Aldehyde Dehydrogenase 6 Family Member A1 (ALDH6A1) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx315193
Description
ALDH6A1 Antibody (FITC) is a Rabbit Polyclonal against ALDH6A1 conjugated to FITC.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Aldehyde Dehydrogenase 6 Family Member A1 (ALDH6A1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q02252 |
| Gene ID | 4329 |
| NCBI Accession | NP_001265522.1, NM_001278593.1, NP_005580.1, NM_005589.3 |
| OMIM | 603178 |
| Alias | ALDH6A1,MMSDH |
| Background | Antibody anti-ALDH6A1 |
| Status | RUO |
Descripción
ALDH6A1, also known as methylmalonate semialdehyde dehydrogenase (MMSDH), is a mitochondrial enzyme involved in the catabolism of branched-chain amino acids (valine and thymine) and odd-chain fatty acids. It catalyzes the oxidation of methylmalonate semialdehyde to propionyl-CoA, which is further metabolized into succinyl-CoA, linking amino acid breakdown to the TCA cycle. ALDH6A1 plays a critical role in energy metabolism and maintaining metabolic flexibility during nutrient stress. Dysregulation of ALDH6A1 impairs amino acid and fatty acid metabolism, contributing to metabolic disorders, including methylmalonic aciduria and neurological deficits. Its activity is essential for detoxifying reactive intermediates formed during amino acid catabolism, protecting cells from oxidative stress. ALDH6A1 is particularly important in tissues with high metabolic demands, such as the liver, muscles, and brain.
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