Aldehyde Dehydrogenase 6 Family Member A1 (ALDH6A1) Antibody (FITC)

Este producto es parte de ALDH - Aldehyde dehydrogenase family member
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169€ (20 µg)

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935106861
info@markelab.com
name
Aldehyde Dehydrogenase 6 Family Member A1 (ALDH6A1) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx315193

Description

ALDH6A1 Antibody (FITC) is a Rabbit Polyclonal against ALDH6A1 conjugated to FITC.

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryPrimary Antibodies
Immunogen TargetAldehyde Dehydrogenase 6 Family Member A1 (ALDH6A1)
HostRabbit
ReactivityHuman
Recommended DilutionOptimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationFITC
IsotypeIgG
Purity> 95%
PurificationPurified by Protein G.
Size 120 µg
Size 250 µg
Size 3100 µg
Size 4200 µg
Size 51 mg
FormLiquid
Buffer0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
AvailabilityShipped within 5-10 working days.
StorageAliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDQ02252
Gene ID4329
NCBI AccessionNP_001265522.1, NM_001278593.1, NP_005580.1, NM_005589.3
OMIM603178
AliasALDH6A1,MMSDH
BackgroundAntibody anti-ALDH6A1
StatusRUO

Descripción

ALDH6A1, also known as methylmalonate semialdehyde dehydrogenase (MMSDH), is a mitochondrial enzyme involved in the catabolism of branched-chain amino acids (valine and thymine) and odd-chain fatty acids. It catalyzes the oxidation of methylmalonate semialdehyde to propionyl-CoA, which is further metabolized into succinyl-CoA, linking amino acid breakdown to the TCA cycle. ALDH6A1 plays a critical role in energy metabolism and maintaining metabolic flexibility during nutrient stress. Dysregulation of ALDH6A1 impairs amino acid and fatty acid metabolism, contributing to metabolic disorders, including methylmalonic aciduria and neurological deficits. Its activity is essential for detoxifying reactive intermediates formed during amino acid catabolism, protecting cells from oxidative stress. ALDH6A1 is particularly important in tissues with high metabolic demands, such as the liver, muscles, and brain.

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