Aldehyde Dehydrogenase 6 Family Member A1 (ALDH6A1) Antibody
260€ (50 µl)
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935106861
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name
Aldehyde Dehydrogenase 6 Family Member A1 (ALDH6A1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx242057
tested applications
ELISA, WB, IHC
Description
ALDH6A1 Antibody is a Rabbit Polyclonal against ALDH6A1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Aldehyde Dehydrogenase 6 Family Member A1 (ALDH6A1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/2000 - 1/5000, WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q02252 |
| Gene ID | 4329 |
| Alias | ALDH6A1,MMSDH |
| Background | Antibody anti-ALDH6A1 |
| Status | RUO |
Descripción
ALDH6A1, also known as methylmalonate semialdehyde dehydrogenase (MMSDH), is a mitochondrial enzyme involved in the catabolism of branched-chain amino acids (valine and thymine) and odd-chain fatty acids. It catalyzes the oxidation of methylmalonate semialdehyde to propionyl-CoA, which is further metabolized into succinyl-CoA, linking amino acid breakdown to the TCA cycle. ALDH6A1 plays a critical role in energy metabolism and maintaining metabolic flexibility during nutrient stress. Dysregulation of ALDH6A1 impairs amino acid and fatty acid metabolism, contributing to metabolic disorders, including methylmalonic aciduria and neurological deficits. Its activity is essential for detoxifying reactive intermediates formed during amino acid catabolism, protecting cells from oxidative stress. ALDH6A1 is particularly important in tissues with high metabolic demands, such as the liver, muscles, and brain.
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