Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1) Antibody
819€ (1 ml)
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Name
Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx171143
Tested Applications
WB, IHC, IF/ICC
Description
This product is currently in development. The lead time for this product may be several months. Please contact us at
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ALDH3A1,ALDH3,ALDHIII |
| Background | Antibody anti-ALDH3A1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ALDH3A1 is a cytosolic enzyme that metabolizes aldehydes derived from lipid peroxidation, environmental toxins, and chemotherapeutic agents. It is highly expressed in the cornea, where it protects ocular tissues from UV-induced oxidative stress and maintains transparency. ALDH3A1 detoxifies reactive aldehydes such as 4-HNE and malondialdehyde, preventing protein and DNA damage under oxidative conditions. It also contributes to cellular antioxidant defenses by generating NADPH, which supports glutathione regeneration. Overexpression of ALDH3A1 has been observed in various cancers, where it promotes resistance to chemotherapy and radiation by neutralizing toxic aldehydes. ALDH3A1’s ability to regulate cell proliferation and survival makes it a target for cancer therapy, particularly in chemoresistant tumors. In addition, its role in protecting ocular tissues highlights its therapeutic potential for preventing UV-induced eye damage and cataract formation.
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