Aldehyde Dehydrogenase 3 Family Member A1 (ALDH3A1) Antibody
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Description
Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. ALDH3A1 forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. The enzyme is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Aldehyde Dehydrogenase 3 Family Member A1 (ALDH3A1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P30838 |
| Alias | ALDH3A1,ALDH3,ALDHIII |
| Background | Antibody anti-ALDH3A1 |
| Status | RUO |
Descripción
ALDH3A1 is a cytosolic enzyme that metabolizes aldehydes derived from lipid peroxidation, environmental toxins, and chemotherapeutic agents. It is highly expressed in the cornea, where it protects ocular tissues from UV-induced oxidative stress and maintains transparency. ALDH3A1 detoxifies reactive aldehydes such as 4-HNE and malondialdehyde, preventing protein and DNA damage under oxidative conditions. It also contributes to cellular antioxidant defenses by generating NADPH, which supports glutathione regeneration. Overexpression of ALDH3A1 has been observed in various cancers, where it promotes resistance to chemotherapy and radiation by neutralizing toxic aldehydes. ALDH3A1’s ability to regulate cell proliferation and survival makes it a target for cancer therapy, particularly in chemoresistant tumors. In addition, its role in protecting ocular tissues highlights its therapeutic potential for preventing UV-induced eye damage and cataract formation.
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Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified.
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