Aldehyde Dehydrogenase 3 Family Member A1 (ALDH3A1) Antibody

Este producto es parte de ALDH - Aldehyde dehydrogenase family member
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169€ (20 µg)

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935106861
info@markelab.com
name
Aldehyde Dehydrogenase 3 Family Member A1 (ALDH3A1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx302452
tested applications
ELISA, WB, IHC, IF/ICC

Description

ALDH3A1 Antibody is a Rabbit Polyclonal against ALDH3A1.

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Data sheet
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Product specifications

CategoryPrimary Antibodies
Immunogen TargetAldehyde Dehydrogenase 3 Family Member A1 (ALDH3A1)
HostRabbit
ReactivityHuman
Recommended DilutionWB: 1/200 - 1/2000, IHC: 1/20 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationUnconjugated
IsotypeIgG
Purity> 95%
PurificationPurified by Protein G.
Size 120 µg
Size 250 µg
Size 3100 µg
Size 4200 µg
Size 51 mg
FormLiquid
Tested ApplicationsELISA, WB, IHC, IF/ICC
Buffer0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
AvailabilityShipped within 5-10 working days.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDP30838
Gene ID218
OMIM100660
AliasALDH3A1,ALDH3,ALDHIII
BackgroundAntibody anti-ALDH3A1
StatusRUO

ALDH3A1 is a cytosolic enzyme that metabolizes aldehydes derived from lipid peroxidation, environmental toxins, and chemotherapeutic agents. It is highly expressed in the cornea, where it protects ocular tissues from UV-induced oxidative stress and maintains transparency. ALDH3A1 detoxifies reactive aldehydes such as 4-HNE and malondialdehyde, preventing protein and DNA damage under oxidative conditions. It also contributes to cellular antioxidant defenses by generating NADPH, which supports glutathione regeneration. Overexpression of ALDH3A1 has been observed in various cancers, where it promotes resistance to chemotherapy and radiation by neutralizing toxic aldehydes. ALDH3A1’s ability to regulate cell proliferation and survival makes it a target for cancer therapy, particularly in chemoresistant tumors. In addition, its role in protecting ocular tissues highlights its therapeutic potential for preventing UV-induced eye damage and cataract formation.

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Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified.

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