Aldehyde Dehydrogenase 1 Family, Member B1 (ALDH1B1) Antibody
273€ (100 µl)
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935106861
info@markelab.com
name
Aldehyde Dehydrogenase 1 Family, Member B1 (ALDH1B1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx132210
tested applications
WB, IHC, IF/ICC
Description
Aldehyde Dehydrogenase 1 Family, Member B1 (ALDH1B1) Antibody is a Rabbit Polyclonal against Aldehyde Dehydrogenase 1 Family, Member B1 (ALDH1B1).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Aldehyde Dehydrogenase 1 Family, Member B1 (ALDH1B1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ALDH1B1,ALDH5,ALDHX |
| Background | Antibody anti-ALDH1B1 |
| Status | RUO |
Descripción
ALDH1B1 is a mitochondrial enzyme that participates in the detoxification of aldehydes and the oxidation of acetaldehyde to acetate, a key step in ethanol metabolism. It is highly expressed in the liver, colon, and gastrointestinal tract, where it protects against oxidative stress and aldehyde-induced cellular damage. ALDH1B1 has been linked to alcohol metabolism, and its dysregulation contributes to alcohol-induced liver injury, cirrhosis, and colorectal cancer. In cancers, ALDH1B1 expression is often elevated, particularly in colorectal and pancreatic tumors, where it promotes tumorigenesis by maintaining cellular redox balance and enhancing proliferation. It also contributes to cancer stem-like properties, facilitating chemoresistance and tumor progression. Studies suggest ALDH1B1 as a promising biomarker and therapeutic target in gastrointestinal cancers and alcohol-associated diseases. Its role in mitochondrial aldehyde metabolism also links it to energy homeostasis and metabolic regulation.
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