Alcohol Dehydrogenase Class-3 (ADH5) Antibody
637€ (100 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Alcohol Dehydrogenase Class-3 (ADH5) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx110908
tested applications
ELISA, WB, IHC
Description
Alcohol Dehydrogenase 5 (Class Iii), Chi Polypeptide Antibody is a Rabbit Polyclonal antibody against Alcohol Dehydrogenase 5 (Class Iii), Chi Polypeptide.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Alcohol Dehydrogenase Class-3 (ADH5) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P11766 |
| Gene ID | 128 |
| OMIM | 103710 |
| Alias | Adh-5,Adh3,GSNOR |
| Background | Antibody anti-ADH5 |
| Status | RUO |
Descripción
ADH5, also known as formaldehyde dehydrogenase, is ubiquitously expressed and functions primarily in the detoxification of formaldehyde, a toxic metabolic byproduct. It catalyzes the oxidation of formaldehyde to formate, using glutathione as a cofactor, and plays a critical role in cellular defense against formaldehyde-induced toxicity and oxidative stress. ADH5 is less active in ethanol metabolism compared to other ADH enzymes but is crucial for maintaining cellular homeostasis and protecting against DNA and protein damage caused by aldehyde accumulation. Its ubiquitous expression highlights its systemic importance in detoxification pathways. Dysregulation of ADH5 is associated with increased susceptibility to formaldehyde-related toxicities and may contribute to cancer progression in tissues exposed to high levels of formaldehyde. Mutations or polymorphisms in ADH5 can impair detoxification efficiency, exacerbating cellular stress and damage.
