Human Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide (ADH5) Protein
234€ (5 µg)
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Name
Human Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide (ADH5) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx073337
Tested Applications
SDS-PAGE
Description
Alcohol Dehydrogenase 5 is a recombinant enzyme.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide (ADH5) |
| Host | E. coli |
| Assay Type | Activity: Not tested |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Human |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Storage | Store at 4°C if the entire vial will be used within 2-4 weeks. Store at -20 °C for long term storage. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P11766 |
| Alias | Adh-5,Adh3,GSNOR |
| Background | Protein ADH5 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ADH5, also known as formaldehyde dehydrogenase, is ubiquitously expressed and functions primarily in the detoxification of formaldehyde, a toxic metabolic byproduct. It catalyzes the oxidation of formaldehyde to formate, using glutathione as a cofactor, and plays a critical role in cellular defense against formaldehyde-induced toxicity and oxidative stress. ADH5 is less active in ethanol metabolism compared to other ADH enzymes but is crucial for maintaining cellular homeostasis and protecting against DNA and protein damage caused by aldehyde accumulation. Its ubiquitous expression highlights its systemic importance in detoxification pathways. Dysregulation of ADH5 is associated with increased susceptibility to formaldehyde-related toxicities and may contribute to cancer progression in tissues exposed to high levels of formaldehyde. Mutations or polymorphisms in ADH5 can impair detoxification efficiency, exacerbating cellular stress and damage.
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