Alcohol Dehydrogenase 1B (ADH1B) Antibody
260€ (50 µl)
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Name
Alcohol Dehydrogenase 1B (ADH1B) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx339558
Tested Applications
ELISA, WB, IHC
Description
ADH1B Antibody is a Rabbit Polyclonal against ADH1B.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Alcohol Dehydrogenase 1B (ADH1B) Immunogen: Synthetic peptide of human ADH1B. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/1000 - 1/2000, WB: 1/200 - 1/1000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P00325 |
| Gene ID | 125 |
| Alias | ADH1B,ADH2, HEL-S-117 |
| Background | Antibody anti-ADH1B |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ADH1B encodes the beta subunit of class I ADH enzymes, which are highly active in the oxidation of ethanol to acetaldehyde. This subunit is particularly important in liver and stomach tissues, where alcohol metabolism is initiated. Polymorphisms in the ADH1B gene, such as the ADH1B2 and ADH1B3 variants, are known to significantly alter enzyme activity. These variants exhibit faster ethanol oxidation rates and are associated with reduced risks of alcohol dependence and increased susceptibility to alcohol-induced flushing. ADH1B also participates in the metabolism of other alcohols and aldehydes, influencing various physiological and pathological processes. Its role in retinol metabolism connects it to pathways involved in vision and cell differentiation. Dysregulation of ADH1B activity has implications for alcohol-related liver diseases and certain cancers, particularly those of the gastrointestinal tract, where acetaldehyde accumulation is a risk factor.
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