AKT Serine/threonine Kinase 1 Phospho-Ser473 (AKT1 pS473) Antibody
429€ (100 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
AKT Serine/threonine Kinase 1 Phospho-Ser473 (AKT1 pS473) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx333257
tested applications
ELISA, WB, IHC
Description
AKT1 (pS473) Antibody is a Rabbit Polyclonal against AKT1 (pS473).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | AKT Serine/threonine Kinase 1 Phospho-Ser473 (AKT1 pS473) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Data | Modification: Phosphorylation // Target Modification: Ser473 |
| Recommended Dilution | WB: 1/500 - 1/1000, IHC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS (without Mg2+ and Ca2+), pH 7.4, containing 150mM NaCl, 0.02% sodium azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P31749 |
| Gene ID | 207 |
| Alias | AKT1,PKB,RAC,RAC-ALPHA |
| Background | Antibody anti-AKT1 |
| Status | RUO |
Descripción
The AKT (also known as Protein Kinase B) is a pivotal enzyme involved in regulating various cellular processes like metabolism, proliferation, survival, and growth. It acts downstream of phosphoinositide 3-kinase (PI3K) signaling pathway, which is activated by growth factors and cytokines. RAC-alpha serine/threonine-protein kinase is the full name of AKT. It belongs to the AGC (protein kinase A/protein kinase G/protein kinase C) family of kinases. AKT has three isoforms: AKT1, AKT2, and AKT3. Each isoform has slightly different tissue distributions and roles but shares the same basic structure and mechanism of action.Activation of AKT typically occurs through phosphorylation at two key residues: threonine 308 (Thr308) and serine 473 (Ser473). Once activated, AKT phosphorylates various downstream targets, including transcription factors, metabolic enzymes, and cell cycle regulators, ultimately leading to diverse cellular responses. Dysregulation of AKT signaling is implicated in various diseases, including cancer, diabetes, and cardiovascular diseases. Therefore, AKT has emerged as a significant target for therapeutic interventions in these conditions.
Related Products
Human AKT1 (RAC-alpha serine/threonine-protein kinase) ELISA Kit
Ver Producto
Mouse AKT1 (RAC-alpha serine/threonine-protein kinase) ELISA Kit
Ver Producto