AKAP13 Cell ELISA Kit
513.5€ (96 tests)
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name
AKAP13 Cell ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx595818
tested applications
ELISA
Description
AKAP13 Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | AKAP13 |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Tested Applications | ELISA |
| Availability | Shipped within 1-2 weeks. The validity for this kit is at least 6 months |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q12802 |
| Gene ID | 11214 |
| OMIM | 604686 |
| Alias | AKAP-13,AKAP-Lbc,ARHGEF13 |
| Background | Elisa kits for AKAP13 |
| Status | RUO |
| Note | Validity: 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
AKAP13, also known as BRX (BRE-1-related exchange factor), is a scaffold protein that not only binds PKA but also acts as a guanine nucleotide exchange factor (GEF) for Rho family GTPases, such as RhoA. AKAP13 plays a critical role in the regulation of cytoskeletal dynamics, cell migration, and proliferation through crosstalk between PKA and Rho signaling pathways. Its Rho-GEF activity regulates actin cytoskeleton organization, influencing processes like adhesion, morphogenesis, and stress fiber formation. AKAP13 is a key regulator of cardiac hypertrophy and heart development, where it mediates PKA and RhoA signaling in cardiomyocytes under mechanical stress. Dysregulation of AKAP13 has been implicated in cancer progression, as it promotes tumor cell motility and invasion through enhanced cytoskeletal reorganization and focal adhesion dynamics. AKAP13 also interacts with steroid hormone receptors, such as estrogen and glucocorticoid receptors, linking it to transcriptional regulation in hormonal signaling pathways. Studies show that AKAP13 mutations are associated with developmental disorders, cardiac anomalies, and hormone-driven cancers.
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