Aflatoxin B1 Aldehyde Reductase Member 3 (AKR7A3) Antibody
169€ (20 µl)
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Name
Aflatoxin B1 Aldehyde Reductase Member 3 (AKR7A3) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx320449
Tested Applications
ELISA, IHC
Description
AKR7A3 Antibody is a Rabbit Polyclonal against AKR7A3.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Aflatoxin B1 Aldehyde Reductase Member 3 (AKR7A3) Immunogen: Recombinant human Aflatoxin B1 aldehyde reductase member 3 protein (1-331AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O95154 |
| Gene ID | 22977 |
| OMIM | 608477 |
| Alias | AKR7A3,AFAR2 |
| Background | Antibody anti-AKR7A3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AKR7A3 shares significant structural and functional similarity with AKR7A2 and is involved in detoxifying aflatoxin B1-derived reactive aldehydes and other toxic carbonyl compounds. It functions as a critical enzyme in aldehyde metabolism, protecting cells from the damaging effects of reactive aldehydes produced during oxidative stress, lipid peroxidation, and xenobiotic metabolism. AKR7A3 is expressed in the liver and gastrointestinal tissues, where it contributes to the defense against dietary toxins, including aflatoxins and other environmental carcinogens. Its ability to detoxify lipid peroxidation products like 4-HNE and malondialdehyde highlights its role in preventing oxidative stress-related cellular damage and carcinogenesis. AKR7A3 also plays a role in maintaining liver homeostasis and mitigating toxin-induced liver injury. Dysregulation or reduced expression of AKR7A3 can increase susceptibility to liver cancer and chronic liver diseases by promoting the accumulation of reactive aldehydes and subsequent DNA damage. Emerging research focuses on its potential as a biomarker for toxin exposure and a target for improving antioxidant defenses in liver-related disorders.
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