Aflatoxin B1 Aldehyde Reductase Member 3 (AKR7A3) Antibody
234€ (5 µg)
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name
Aflatoxin B1 Aldehyde Reductase Member 3 (AKR7A3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx137261
Description
Aflatoxin B1 Aldehyde Reductase Member 3 (AKR7A3) Antibody is a Mouse Monoclonal antibody against Aflatoxin B1 Aldehyde Reductase Member 3 (AKR7A3).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Aflatoxin B1 Aldehyde Reductase Member 3 (AKR7A3) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 100 µg |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| Alias | AKR7A3,AFAR2 |
| Background | Antibody anti-AKR7A3 |
| Status | RUO |
Descripción
AKR7A3 shares significant structural and functional similarity with AKR7A2 and is involved in detoxifying aflatoxin B1-derived reactive aldehydes and other toxic carbonyl compounds. It functions as a critical enzyme in aldehyde metabolism, protecting cells from the damaging effects of reactive aldehydes produced during oxidative stress, lipid peroxidation, and xenobiotic metabolism. AKR7A3 is expressed in the liver and gastrointestinal tissues, where it contributes to the defense against dietary toxins, including aflatoxins and other environmental carcinogens. Its ability to detoxify lipid peroxidation products like 4-HNE and malondialdehyde highlights its role in preventing oxidative stress-related cellular damage and carcinogenesis. AKR7A3 also plays a role in maintaining liver homeostasis and mitigating toxin-induced liver injury. Dysregulation or reduced expression of AKR7A3 can increase susceptibility to liver cancer and chronic liver diseases by promoting the accumulation of reactive aldehydes and subsequent DNA damage. Emerging research focuses on its potential as a biomarker for toxin exposure and a target for improving antioxidant defenses in liver-related disorders.
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