Advanced Glycosylation End Product Specific Receptor (AGER) Antibody Pair

Este producto es parte de AGE - Advanced Glycation End Product (Receptor)
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1495€ (5 × 96 tests)

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935106861
info@markelab.com
name
Advanced Glycosylation End Product Specific Receptor (AGER) Antibody Pair
category
Antibody Pairs
provider
Abbexa
reference
abx370664
tested applications
ELISA

Description

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody Pair for use in Sandwich ELISA assay development. 

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryAntibody Pairs
Immunogen TargetAdvanced Glycosylation End Product Specific Receptor (AGER)
ReactivityRat
Assay DataDetection Antibody Biotinilated
Assay TypeSandwich
Recommended DilutionDilute the Capture Antibody 125-fold with Coating Buffer. Dilute the Biotin-Conjugated Detection Antibody 200-fold with Detection Antibody Diluent. Optimal dilutions/concentrations should be determined by the end user.
Size 15 × 96 tests
Size 210 × 96 tests
FormStandard: Lyophilized--Liquid (Capture Antibody and Detection Antibody) Reconstitute the standard with Standard Diluent. The volume, and therefore standard concentration, should be determined by the end user.
Tested ApplicationsELISA
BufferThe Capture and Detection Antibody both contain 0.1% sodium azide.
AvailabilityPlease enquire.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry IceNo
AliasRAGE,SCARJ1,sRAGE
BackgroundAntibody Pair for AGER
StatusRUO
NoteThis antibody pair contains ( 5 x 96 det): Detection: 50 µg Capture: 200 µg Standard: 2 µg This product is for research use only.

Descripción

AGER, also known as RAGE (Receptor for Advanced Glycation End Products), is a transmembrane receptor belonging to the immunoglobulin superfamily that binds to AGEs and other ligands such as S100 proteins, HMGB1, and amyloid-β. AGER is widely expressed, particularly in the endothelium, lungs, brain, and immune cells, and plays a critical role in inflammatory and oxidative stress signaling. Binding of AGEs to AGER activates downstream pathways, including NF-κB, MAPK, and JAK/STAT, leading to the production of pro-inflammatory cytokines and reactive oxygen species. Overexpression or chronic activation of AGER is associated with diseases such as diabetes complications, atherosclerosis, Alzheimer’s disease, and cancer, where it exacerbates inflammation and tissue damage. AGER is a promising therapeutic target for reducing AGE-mediated pathologies and modulating immune and metabolic dysfunction.

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