Adrenocortical Dysplasia Homolog (ACD) Antibody
195€ (20 µl)
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Name
Adrenocortical Dysplasia Homolog (ACD) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx125486
Tested Applications
ELISA, WB
Description
ACD Antibody is a Rabbit Polyclonal against ACD.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Adrenocortical Dysplasia Homolog (ACD) Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ACD. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: > 0.2 mg/ml |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 49 kDa Observed MW: 58 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96AP0 |
| Gene ID | 65057 |
| NCBI Accession | NP_001075955.1 |
| Alias | ACD,PIP1,PTOP,TINT1,TPP1,adrenocortical dysplasia homolog shelterin complex subunit and telomerase recruitment factor |
| Background | Antibody anti-ACD |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ACD, also known as TPP1, is a shelterin complex component involved in protecting telomeres and maintaining chromosomal stability. It regulates telomere length and integrity by recruiting telomerase and interacting with other shelterin proteins, such as POT1, to prevent inappropriate DNA damage responses at chromosome ends. ACD plays a critical role in cellular aging, genome stability, and cancer suppression. It is expressed in proliferative tissues, where telomere maintenance is essential for cellular replication. Dysregulation or mutations in ACD are associated with telomere-related disorders, such as dyskeratosis congenita and aplastic anemia, as well as increased susceptibility to cancer due to compromised chromosomal stability. ACD’s functions in telomere biology underscore its importance in aging, genome integrity, and disease prevention.
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