Adrenoceptor Beta 2 Phospho-Ser346 (ADRB2 pS346) Antibody
429€ (100 µl)
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935106861
info@markelab.com
name
Adrenoceptor Beta 2 Phospho-Ser346 (ADRB2 pS346) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx332919
tested applications
ELISA, WB
Description
ADRB2 (pS346) Antibody is a Rabbit Polyclonal against ADRB2 (pS346).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Adrenoceptor Beta 2 Phospho-Ser346 (ADRB2 pS346) |
| Host | Rabbit |
| Reactivity | Human |
| Assay Data | Modification: Phosphorylation // Target Modification: Ser346 |
| Recommended Dilution | WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg2+ and Ca2+), pH 7.4, containing 150mM NaCl, 0.02% sodium azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P07550 |
| Alias | ADRB2,ADRB2R,ADRBR,B2AR,Adrb-2,beta 2-AR,Gpcr7,BAR,ARB2 |
| Background | Antibody anti-ADRB2 |
| Status | RUO |
Descripción
The adrenergic receptor beta-2 (ADRB2) is another G-protein-coupled receptor widely distributed in smooth muscle tissues, including the lungs, blood vessels, and uterus. ADRB2 activation by catecholamines induces smooth muscle relaxation through cAMP-mediated pathways, leading to bronchodilation, vasodilation, and uterine relaxation. In the respiratory system, ADRB2 is critical for airway relaxation, making it a primary target for bronchodilators used in asthma and chronic obstructive pulmonary disease (COPD) management. Additionally, ADRB2 plays a role in glycogenolysis in the liver and skeletal muscles, promoting energy mobilization during stress or exercise. Genetic variants in ADRB2, such as Gly16Arg and Gln27Glu, influence receptor sensitivity and have been associated with differential responses to beta-agonists and susceptibility to asthma. Overactivation of ADRB2 can lead to desensitization, reducing therapeutic efficacy over time. Its involvement in multiple physiological processes underscores ADRB2's importance in both metabolic and respiratory regulation.
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