Adrenoceptor Beta 2 (ADRB2) Antibody

Este producto es parte de ADRB - Adrenergic receptor Beta
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221€ (50 µg)

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935106861
info@markelab.com
name
Adrenoceptor Beta 2 (ADRB2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx324955
tested applications
ELISA, WB, IHC, IF/ICC

Description

ADRB2 Antibody is a Rabbit Polyclonal against ADRB2.

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryPrimary Antibodies
Immunogen TargetAdrenoceptor Beta 2 (ADRB2)
HostRabbit
ReactivityHuman
Recommended DilutionELISA: 1/5000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationUnconjugated
IsotypeIgG
PurificationPurified by affinity chromatography.
Size 150 µg
Size 2100 µg
FormLiquid
Tested ApplicationsELISA, WB, IHC, IF/ICC
BufferPBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
AvailabilityShipped within 5-10 working days.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDP07550
Gene ID154
AliasADRB2,ADRB2R,ADRBR,B2AR,Adrb-2,beta 2-AR,Gpcr7,BAR,ARB2
BackgroundAntibody anti-ADRB2
StatusRUO

The adrenergic receptor beta-2 (ADRB2) is another G-protein-coupled receptor widely distributed in smooth muscle tissues, including the lungs, blood vessels, and uterus. ADRB2 activation by catecholamines induces smooth muscle relaxation through cAMP-mediated pathways, leading to bronchodilation, vasodilation, and uterine relaxation. In the respiratory system, ADRB2 is critical for airway relaxation, making it a primary target for bronchodilators used in asthma and chronic obstructive pulmonary disease (COPD) management. Additionally, ADRB2 plays a role in glycogenolysis in the liver and skeletal muscles, promoting energy mobilization during stress or exercise. Genetic variants in ADRB2, such as Gly16Arg and Gln27Glu, influence receptor sensitivity and have been associated with differential responses to beta-agonists and susceptibility to asthma. Overactivation of ADRB2 can lead to desensitization, reducing therapeutic efficacy over time. Its involvement in multiple physiological processes underscores ADRB2's importance in both metabolic and respiratory regulation.

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