Adrenergic Receptor Beta 1 (ADRB1) Antibody

Este producto es parte de ADRB - Adrenergic receptor Beta
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260€ (50 µl)

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935106861
info@markelab.com
name
Adrenergic Receptor Beta 1 (ADRB1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx214470
tested applications
ELISA, IHC

Description

ADRB1 Antibody is a Rabbit Polyclonal against ADRB1.

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryPrimary Antibodies
Immunogen TargetAdrenergic Receptor Beta 1 (ADRB1)
HostRabbit
ReactivityHuman, Mouse, Rat
Recommended DilutionELISA: 1/1000 - 1/5000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationUnconjugated
IsotypeIgG
PurificationAntigen Affinity Chromatography.
Size 150 µl
Size 2100 µl
FormLiquid
Tested ApplicationsELISA, IHC
BufferPBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol.
AvailabilityShipped within 5-10 working days.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDP08588
Gene ID153
AliasADRB1,ADRB1R,Adrenergic receptor beta 1,RHR,B1AR,FNSS2,BETA1AR
BackgroundAntibody anti-ADRB1
StatusRUO

The adrenergic receptor beta-1 (ADRB1) is a G-protein-coupled receptor that plays a critical role in cardiovascular physiology. Predominantly expressed in the heart, kidneys, and adipose tissues, ADRB1 mediates the effects of catecholamines such as epinephrine and norepinephrine. Upon activation, ADRB1 stimulates adenylate cyclase through Gs proteins, leading to increased cAMP production. This process enhances heart rate (positive chronotropy), contractility (positive inotropy), and conduction velocity (positive dromotropy), making it essential for the regulation of cardiac output. ADRB1 also influences renin secretion from the kidneys, impacting blood pressure regulation. Polymorphisms in the ADRB1 gene, such as Ser49Gly and Arg389Gly, have been linked to altered receptor activity, influencing individual responses to stress, exercise, and beta-blocker therapies. Dysregulation or overstimulation of ADRB1 is associated with conditions such as hypertension, heart failure, and arrhythmias, underscoring its significance as a therapeutic target in cardiovascular diseases.

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