Adenylate Kinase 2, Mitochondrial (AK2) Antibody
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935106861
info@markelab.com
Precio
169€ (20 µl)
Antibody anti-AK2
proveedor
Abbexareference
abx322230Tested Applications
ELISA, WB, IHCreactivity
Human, Mousestatus
RUOclonality
PolyclonalDescripción
AK2 Antibody is a Rabbit Polyclonal against AK2.
Background
AK2 is localized in the mitochondrial intermembrane space and is primarily responsible for ATP production in hematopoietic cells. AK2 catalyzes the same ADP-to-ATP conversion as AK1 but in the mitochondrial compartment, essential for maintaining cellular energy supply. Mutations in AK2 are linked to reticular dysgenesis, a severe immunodeficiency caused by disrupted leukocyte differentiation. AK2 has critical functions in energy homeostasis during apoptosis, as ATP signaling is necessary for programmed cell death. Its role extends to regulating mitochondrial biogenesis and influencing mitochondrial DNA replication. The expression of AK2 is also vital in early embryonic development and immune system maintenance.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse
immunogen target
Adenylate Kinase 2, Mitochondrial (AK2)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC
purification
Antigen Affinity Chromatography.
recommended dilution
WB: 1/500 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol.
size 1
20 µl
size 2
50 µl
size 3
100 µl
size 4
200 µl
size 5
1 ml
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
AK2
dry ice
No
availability
Shipped within 5-10 working days.
alias
ADK2
uniprot id
NCBI accession
NP_001186128.1, NM_001199199.1, NP_001306068.1, NM_001319139.1, NP_001306069.1, NM_001319140.1, NP_001616.1, NM_001625.3
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