Adenylate Kinase 2, Mitochondrial (AK2) Antibody
169€ (20 µl)
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Name
Adenylate Kinase 2, Mitochondrial (AK2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx322230
Tested Applications
ELISA, WB, IHC
Description
AK2 Antibody is a Rabbit Polyclonal against AK2.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Adenylate Kinase 2, Mitochondrial (AK2) Immunogen: Recombinant Adenylate kinase 2, mitochondrial protein (1-232AA). |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P54819 |
| Gene ID | 204 |
| NCBI Accession | NP_001186128.1, NM_001199199.1, NP_001306068.1, NM_001319139.1, NP_001306069.1, NM_001319140.1, NP_001616.1, NM_001625.3 |
| OMIM | 103020 |
| Alias | ADK2 |
| Background | Antibody anti-AK2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AK2 is localized in the mitochondrial intermembrane space and is primarily responsible for ATP production in hematopoietic cells. AK2 catalyzes the same ADP-to-ATP conversion as AK1 but in the mitochondrial compartment, essential for maintaining cellular energy supply. Mutations in AK2 are linked to reticular dysgenesis, a severe immunodeficiency caused by disrupted leukocyte differentiation. AK2 has critical functions in energy homeostasis during apoptosis, as ATP signaling is necessary for programmed cell death. Its role extends to regulating mitochondrial biogenesis and influencing mitochondrial DNA replication. The expression of AK2 is also vital in early embryonic development and immune system maintenance.
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