Adenylate Kinase 2, Mitochondrial (AK2) Antibody
292.5€ (80 µl)
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Name
Adenylate Kinase 2, Mitochondrial (AK2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx033892
Tested Applications
ELISA, WB, IHC
Description
Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Adenylate Kinase 2, Mitochondrial (AK2) Immunogen: KLH-conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human AK2. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 26.5 kDa |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P54819 |
| NCBI Accession | NP_001186128.1, NP_001616.1, NP_037543.1 |
| Alias | ADK2 |
| Background | Antibody anti-AK2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AK2 is localized in the mitochondrial intermembrane space and is primarily responsible for ATP production in hematopoietic cells. AK2 catalyzes the same ADP-to-ATP conversion as AK1 but in the mitochondrial compartment, essential for maintaining cellular energy supply. Mutations in AK2 are linked to reticular dysgenesis, a severe immunodeficiency caused by disrupted leukocyte differentiation. AK2 has critical functions in energy homeostasis during apoptosis, as ATP signaling is necessary for programmed cell death. Its role extends to regulating mitochondrial biogenesis and influencing mitochondrial DNA replication. The expression of AK2 is also vital in early embryonic development and immune system maintenance.
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