Adenosine Deaminase (ADA) Antibody
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935106861
info@markelab.com
Precio
350€ (100 µg)
Antibody anti-ADA
proveedor
Abbexareference
abx230135Tested Applications
ELISA, WB, IHCreactivity
Human, Mousestatus
RUOclonality
PolyclonalDescripción
ADA Antibody is a Rabbit Polyclonal against ADA.
Background
Adenosine deaminase (ADA) is an enzyme crucial in purine metabolism, responsible for catalyzing the irreversible deamination of adenosine and deoxyadenosine to inosine and deoxyinosine, respectively. ADA is predominantly found in lymphocytes, with high activity in tissues such as the thymus, spleen, and bone marrow. It is vital for the development and maintenance of the immune system, as its deficiency leads to the accumulation of toxic purine metabolites, which impair DNA synthesis and lymphocyte survival. Mutations in the ADA gene result in severe combined immunodeficiency (SCID), characterized by a lack of functional T, B, and NK cells. ADA is also widely studied as a marker of immune activation and inflammation in conditions like tuberculosis and rheumatoid arthritis. Therapeutic interventions for ADA deficiency include enzyme replacement therapy and gene therapy, both of which aim to restore immune function.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse
immunogen target
Adenosine Deaminase (ADA)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC
purity
≥ 95% (SDS-PAGE)
purification
Purified by immunogen affinity chromatography.
buffer
PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
size 1
100 µg
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
ADA
dry ice
No
availability
Shipped within 5-12 working days.
alias
Adenosine aminohydrolase
uniprot id
note
This product is for research use only.
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