Adenosine Deaminase 2 (ADA2) Antibody (Biotin)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Adenosine Deaminase 2 (ADA2) Antibody (Biotin) is a Rabbit Polyclonal antibody (
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Adenosine Deaminase 2 (ADA2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.5-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 200 µl |
| Size 2 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NZK5 |
| Gene ID | 51816 |
| OMIM | 182410 |
| Alias | ADGF,CECR1,IDGFL |
| Background | Antibody anti-ADA2 |
| Status | RUO |
Descripción
ADA2, encoded by the CECR1 gene, is a secreted protein that belongs to the adenosine deaminase family but has a distinct role compared to ADA. While ADA mainly regulates purine metabolism, ADA2 functions as a growth factor and modulates immune and vascular systems. It plays a significant role in macrophage activation, promoting M2 polarization, and regulating endothelial cell proliferation and angiogenesis. ADA2 is highly expressed in immune-related tissues, particularly monocytes and macrophages. Loss-of-function mutations in ADA2 cause Deficiency of ADA2 (DADA2), an autoinflammatory disorder characterized by systemic vasculitis, early-onset stroke, immunodeficiency, and bone marrow failure. Elevated ADA2 activity has also been linked to tumor progression and inflammation. ADA2 is a critical biomarker and therapeutic target for managing vasculitic and immune-related diseases.
Related Products
Human Adenosine Deaminase 2 (ADA2) ELISA Kit
Human Adenosine Deaminase 2 (ADA2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Adenosine Deaminase 2 (ADA2) concentrations in serum, plasma, tissue homogenates, cell lysates and other biological fluids.
Ver Producto
Adenosine Deaminase 2 (ADA2) Antibody
Adenosine Deaminase 2 (ADA2) Antibody is a Rabbit Polyclonal against Adenosine Deaminase 2 (ADA2).
Ver Producto
Human Adenosine Deaminase 2 (ADA2) ELISA Kit
Human Adenosine Deaminase 2 (ADA2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Adenosine Deaminase 2 (ADA2) concentrations in serum, plasma and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1)
Ver Producto