Adenosine Deaminase 2 (ADA2) Antibody
910€ (1 ml)
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Name
Adenosine Deaminase 2 (ADA2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx171618
Description
This product is currently in development. The lead time for this product may be several months. Please contact us at
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Adenosine Deaminase 2 (ADA2) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB (Predicted): 0.01-2 µg/ml, IHC (Predicted): 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 1 ml |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NZK5 |
| Gene ID | 51816 |
| OMIM | 182410 |
| Alias | ADGF,CECR1,IDGFL |
| Background | Antibody anti-ADA2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ADA2, encoded by the CECR1 gene, is a secreted protein that belongs to the adenosine deaminase family but has a distinct role compared to ADA. While ADA mainly regulates purine metabolism, ADA2 functions as a growth factor and modulates immune and vascular systems. It plays a significant role in macrophage activation, promoting M2 polarization, and regulating endothelial cell proliferation and angiogenesis. ADA2 is highly expressed in immune-related tissues, particularly monocytes and macrophages. Loss-of-function mutations in ADA2 cause Deficiency of ADA2 (DADA2), an autoinflammatory disorder characterized by systemic vasculitis, early-onset stroke, immunodeficiency, and bone marrow failure. Elevated ADA2 activity has also been linked to tumor progression and inflammation. ADA2 is a critical biomarker and therapeutic target for managing vasculitic and immune-related diseases.
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