935106861
info@markelab.com
Precio
875€ (1 ml)
This product is currently in development. The lead time for this product may be several months. Please contact us at info@markelab.com for an updated lead time before purchasing this product. Adenosine Deaminase 2 (ADA2) Antibody is a Mouse Monoclonal antibody against Adenosine Deaminase 2 (ADA2).
ADA2, encoded by the CECR1 gene, is a secreted protein that belongs to the adenosine deaminase family but has a distinct role compared to ADA. While ADA mainly regulates purine metabolism, ADA2 functions as a growth factor and modulates immune and vascular systems. It plays a significant role in macrophage activation, promoting M2 polarization, and regulating endothelial cell proliferation and angiogenesis. ADA2 is highly expressed in immune-related tissues, particularly monocytes and macrophages. Loss-of-function mutations in ADA2 cause Deficiency of ADA2 (DADA2), an autoinflammatory disorder characterized by systemic vasculitis, early-onset stroke, immunodeficiency, and bone marrow failure. Elevated ADA2 activity has also been linked to tumor progression and inflammation. ADA2 is a critical biomarker and therapeutic target for managing vasculitic and immune-related diseases.
Primary Antibodies
Monoclonal
Human
Adenosine Deaminase 2 (ADA2)
Mouse
Unconjugated
Liquid
WB, IHC, IF/ICC
Purified by Protein A and Protein G affinity chromatography.
0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
1 ml
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
ADA2
No
Please enquire.
ADGF,CECR1,IDGFL
This product is for research use only.
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