Adenosine Deaminase 2 (ADA2) Antibody

Este producto es parte de ADA - Adenosine Deaminase
Adenosine Deaminase 2 (ADA2) Antibody

Pida mas información

935106861

info@markelab.com

Precio

910€ (1 ml)

Antibody anti-ADA2

proveedor

Abbexa

reference

abx171618

Tested Applications

WB, IHC, IF/ICC

reactivity

Human

status

RUO

clonality

Monoclonal

Descripción

This product is currently in development. The lead time for this product may be several months. Please contact us at


Background

ADA2, encoded by the CECR1 gene, is a secreted protein that belongs to the adenosine deaminase family but has a distinct role compared to ADA. While ADA mainly regulates purine metabolism, ADA2 functions as a growth factor and modulates immune and vascular systems. It plays a significant role in macrophage activation, promoting M2 polarization, and regulating endothelial cell proliferation and angiogenesis. ADA2 is highly expressed in immune-related tissues, particularly monocytes and macrophages. Loss-of-function mutations in ADA2 cause Deficiency of ADA2 (DADA2), an autoinflammatory disorder characterized by systemic vasculitis, early-onset stroke, immunodeficiency, and bone marrow failure. Elevated ADA2 activity has also been linked to tumor progression and inflammation. ADA2 is a critical biomarker and therapeutic target for managing vasculitic and immune-related diseases.

Características del producto

category

Primary Antibodies


clonality

Monoclonal


reactivity

Human


immunogen target

Adenosine Deaminase 2 (ADA2)


host

Mouse


conjugation

Unconjugated


form

Liquid


tested applications

WB, IHC, IF/ICC


purification

Purified by Protein A and Protein G affinity chromatography.


recommended dilution

WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.


buffer

0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.


size 1

1 ml


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

ADA2


dry ice

No


availability

Please enquire.


alias

ADGF,CECR1,IDGFL


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