ADD1 / 2 Cell ELISA Kit
513.5€ (96 tests)
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Name
ADD1 / 2 Cell ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx595018
Tested Applications
ELISA
Description
ADD1/2 Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.
Documentos del producto
Especificaciones del producto
| Category | ELISA Kits |
| Immunogen Target | ADD1/2 |
| Reactivity | Human, Mouse, Rat |
| Detection Method | Colorimetric |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Tested Applications | ELISA |
| Availability | Shipped within 1-2 weeks. |
| Storage | Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P35611, P35612 |
| Gene ID | 118, 119 |
| OMIM | 102680, 102681 |
| Alias | ADDA,ADDUCIN 1 |
| Background | Elisa Kits for: ADD1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Background
ADD1 encodes alpha-adducin, a cytoskeletal protein that plays a key role in the assembly and maintenance of the actin-spectrin network, a critical component of the cell cortex. Alpha-adducin is primarily expressed in the brain and kidneys, where it contributes to cellular processes such as membrane stability, ion transport regulation, and cell signaling. It is particularly important in erythrocytes, where it stabilizes the spectrin-actin lattice to maintain red blood cell shape and flexibility. Genetic variations in ADD1 have been associated with hypertension and cardiovascular diseases due to its role in modulating sodium transport in renal epithelial cells. Additionally, alpha-adducin is involved in neuronal morphology and synaptic plasticity, highlighting its importance in neural development and function. Dysregulation or mutations can lead to cellular structural defects and associated diseases.
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