ADCK4 Cell ELISA Kit
513.5€ (96 tests)
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name
ADCK4 Cell ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx595930
tested applications
ELISA
Description
ADCK4 Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | ADCK4 |
| Reactivity | Human, Mouse, Rat |
| Detection Method | Colorimetric |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Tested Applications | ELISA |
| Availability | Shipped within 1-2 weeks. The validity for this kit is at least 6 months |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q96D53 |
| Gene ID | 79934 |
| Alias | NPHS9,COQ8B |
| Background | Elisa kits for ADCK4 |
| Status | RUO |
| Note | Validity: 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
aarF domain-containing kinase 4 (ADCK4), also known as COQ8B, is a mitochondrial protein involved in the biosynthesis and regulation of coenzyme Q10 (CoQ10), an essential molecule in the mitochondrial electron transport chain for ATP production. ADCK4 is particularly important in kidney and podocyte function, and mutations in the ADCK4 gene are associated with CoQ10 deficiency-related nephrotic syndrome, which can lead to kidney dysfunction and proteinuria. Beyond its role in mitochondrial bioenergetics, ADCK4 is thought to stabilize CoQ biosynthetic complexes, ensuring efficient electron transport and reducing oxidative stress. ADCK4 dysfunction is linked to mitochondrial diseases, with CoQ10 supplementation often used as a therapeutic strategy to mitigate symptoms and restore energy metabolism.
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