Adapter Molecule Crk (CRK) Antibody
195€ (20 µl)
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935106861
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name
Adapter Molecule Crk (CRK) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx006690
tested applications
ELISA, WB
Description
CRK Antibody is a Rabbit Polyclonal Antibody against CRK.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Adapter Molecule Crk (CRK) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P46108 |
| Gene ID | 1398 |
| NCBI Accession | NP_058431.2 |
| Alias | CRK, CRKII, p38, v-crk avian sarcoma virus CT10 oncogene homolog, CRK proto-oncogene |
| Background | Antibody anti-CRK |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
Proto-oncogene c-Crk (CRK) is an adaptor protein that plays a critical role in various cellular processes, including signal transduction, cellular migration, and proliferation. It does not have enzymatic activity but acts by interacting with other proteins via its SH2 and SH3 domains. These interactions are crucial for the transmission of signals from receptor tyrosine kinases (RTKs) and other cellular receptors, which control processes like cell growth and differentiation. CRK is involved in many pathways, including those related to cell adhesion, cytoskeletal rearrangement, and survival. Its involvement in regulating these processes makes it a key player in cancer biology, where it can function as an oncogene when dysregulated.
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