ADAM Metallopeptidase With Thrombospondin Type 1 Motif 4 (ADAMTS4) Antibody

Product specifications

Primary Antibodies

ADAM Metallopeptidase With Thrombospondin Type 1 Motif 4 (ADAMTS4)

Rabbit

Human, Mouse

WB: 1/500 - 1/5000, IHC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

> 95%

Purified by Protein G.

20 µg

50 µg

100 µg

200 µg

1 mg

Liquid

ELISA, WB, IHC

0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.

Shipped within 5-10 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

O75173

9507

NP_001307265.1, NM_001320336.1, NP_005090.3, NM_005099.5

603876

KIAA0688, Type 1 Motif 4,A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4 ,Aggrecanase-1,ADAM-TS4,ADAMTS-4

Antibody anti-ADAMTS4

RUO

Descripción

ADAMTS4, also known as A Disintegrin And Metalloproteinase with Thrombospondin Motifs 4, is a member of the ADAMTS protein family. ADAMTS4 contains multiple domains, including a metalloproteinase domain responsible for its enzymatic activity, as well as thrombospondin type-1 (TSP-1) motifs. ADAMTS4 is primarily known for its role in extracellular matrix remodeling, particularly in the breakdown of aggrecan, a large proteoglycan found in cartilage. ADAMTS4 cleaves aggrecan at specific sites, leading to the degradation of cartilage matrix and contributing to the pathogenesis of osteoarthritis and other joint-related disorders. It is one of the key enzymes involved in cartilage degradation in osteoarthritis.ADAMTS4 has been implicated in various diseases, particularly osteoarthritis. Elevated levels of ADAMTS4 expression have been observed in osteoarthritic cartilage, synovial fluid, and serum, suggesting its involvement in the disease process. Inhibition of ADAMTS4 activity has been explored as a potential therapeutic strategy for osteoarthritis to prevent cartilage degradation.Research on ADAMTS4 has implications for understanding the pathogenesis of osteoarthritis and other joint-related disorders. Targeting ADAMTS4 activity or expression may represent a promising therapeutic approach for these conditions. Additionally, further research into the regulation and function of ADAMTS4 may provide insights into its roles in normal physiology and other diseases.

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ADAM Metallopeptidase With Thrombospondin Type 1 Motif 4 (ADAMTS4) Antibody

ADAMTS4 Antibody is a Rabbit Polyclonal antibody against ADAMTS4. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.

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