ADAM Metallopeptidase With Thrombospondin Type 1 Motif 17 (ADAMTS17) Antibody
221€ (50 µg)
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935106861
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name
ADAM Metallopeptidase With Thrombospondin Type 1 Motif 17 (ADAMTS17) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx325193
tested applications
ELISA, IHC
Description
ADAMTS17 Antibody is a Rabbit Polyclonal against ADAMTS17.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ADAM Metallopeptidase With Thrombospondin Type 1 Motif 17 (ADAMTS17) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/20000, IHC: 1/100 - 1/300. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8TE56 |
| Gene ID | 170691 |
| Alias | Type 1 Motif 17,A Disintegrin And Metalloproteinase With Thrombospondin Motifs 17,WMS4,ADAMTS-17,ADAM-TS17 |
| Background | Antibody anti-ADAMTS17 |
| Status | RUO |
Descripción
ADAMTS17 (ADAM metallopeptidase with thrombospondin type 1 motif 17) is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS17, like other members of the ADAMTS family, contains several characteristic domains, including a signal peptide, a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and multiple thrombospondin type 1 (TSP1) motifs. ADAMTS17 is expressed in various tissues during development and in adulthood. It is found in tissues such as the heart, lungs, kidneys, and skeletal tissues. ADAMTS17 plays a role in ECM remodeling by cleaving ECM proteins such as aggrecan, versican, and brevican. These proteolytic activities are essential for tissue development, maintenance, and repair.ADAMTS17 is implicated in various aspects of tissue development, particularly in skeletal development. It may play a role in processes such as chondrogenesis (cartilage formation) and osteogenesis (bone formation), where it regulates ECM composition and structure.While specific functions related to inflammation and immunity are less well-characterized for ADAMTS17 compared to other members of the ADAMTS family, its expression patterns in certain immune cells and tissues suggest potential roles in modulating immune responses. ADAMTS17 expression levels have been found to be dysregulated in various cancers, including breast cancer, ovarian cancer, and prostate cancer. Its roles in ECM remodeling and tissue development suggest potential contributions to tumor progression, invasion, and metastasis.
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