ADAM Metallopeptidase Domain 7 (ADAM7) Antibody
260€ (50 µl)
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935106861
info@markelab.com
name
ADAM Metallopeptidase Domain 7 (ADAM7) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx210477
tested applications
ELISA, IHC
Description
ADAM7 Antibody is a Rabbit Polyclonal against ADAM7.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ADAM Metallopeptidase Domain 7 (ADAM7) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/2000 - 1/5000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9H2U9 |
| Gene ID | 8756 |
| Alias | EAPI, GP83,ADAM-7 |
| Background | Antibody anti-ADAM7 |
| Status | RUO |
Descripción
ADAM7 is a member of the ADAMs family, a group distinguished by their zinc protease activity. These transmembrane proteins serve as pivotal players in a myriad of biological processes, orchestrating vital functions such as cell signaling, adhesion, and migration. Despite its classification as a zinc protease, the protein encoded by ADAM7 intriguingly lacks typical protease activity. Instead, it likely operates through mediating protein-protein interactions, thereby modulating essential cellular processes such as cell adhesion. Of particular interest is its potential involvement in facilitating protein-protein interactions and cell adhesion events, including the intricate process of sperm-egg fusion. Through its participation in these adhesive mechanisms, ADAM7 may act as a facilitator in the complex interplay between sperm and egg, ultimately contributing to successful fertilization. Moreover, emerging studies suggest a connection between mutations in the ADAM7 gene and the progression of melanoma, a highly aggressive form of skin cancer. These mutations are hypothesized to disrupt the protein's normal functioning, potentially leading to dysregulated cell adhesion processes and promoting the uncontrolled growth and metastasis of melanoma cells.
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