Acyl-CoA Synthetase Long Chain Family Member 4 (ACSL4) Antibody
260€ (50 µl)
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935106861
info@markelab.com
name
Acyl-CoA Synthetase Long Chain Family Member 4 (ACSL4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx241020
tested applications
ELISA, WB, IHC
Description
ACSL4 Antibody is a Rabbit Polyclonal against ACSL4.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Acyl-CoA Synthetase Long Chain Family Member 4 (ACSL4) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/2000 - 1/10000, WB: 1/1000 - 1/5000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O60488 |
| Gene ID | 2182 |
| Alias | ACS4,FACL4,LACS4 MRX63,MRX68 |
| Background | Antibody anti-ACSL4 |
| Status | RUO |
Descripción
ACSL4 is an acyl-CoA synthetase with a strong preference for polyunsaturated fatty acids, such as arachidonic and docosahexaenoic acids, converting them into acyl-CoA derivatives for metabolic use. It is highly expressed in the brain, testis, and adrenal glands, where it supports processes requiring specialized lipid metabolism, including the biosynthesis of eicosanoids and membrane lipids. ACSL4 is critical in ferroptosis, a type of programmed cell death triggered by lipid peroxidation, through its role in incorporating polyunsaturated fatty acids into phospholipids. Dysregulation of ACSL4 has been linked to cancer, neurodegenerative diseases, and inflammatory disorders, as it influences processes such as oxidative stress and cellular survival. Its specific role in handling polyunsaturated fatty acids highlights its importance in maintaining cellular lipid balance and preventing oxidative damage under stress conditions.
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